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| Scientific Info | | Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy | Two 52-week randomized placebo controlled clinical diabetic neuropathy trials testing
two doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d. Intention-to-treat patients amounted to 1,257 or 93% of enrolled patients. Efficacy end points were sural nerve morphometry, nerve conduction velocities, vibration perception thresholds, clinical symptom scores, and a visual
analogue scale for most bothersome symptom, most notably pain. The two studies were evaluated
separately and combined. Data showed significant improvements in sural nerve fiber numbers and regenerating nerve fiber clusters. Nerve conduction velocities and amplitudes did not improve,whereas vibration perception improved in both studies. Pain as the most bothersome symptom
showed significant improvement in one study and in the combined cohort taking 1,000 mg ALC.
These studies demonstrate that ALC treatment is efficacious in alleviating symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy. |
| Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy. | To assess the efficacy of oral ALCAR (1500 mg twice daily) for up to 33 months in an open cohort of 21 HIV-positive patients with established ATN(antiretroviral toxic neuropathy)
AIDS. 18(11):1549-1560, July 23, 2004.
Hart, Andrew M a,d,*; Wilson, Andrew DH a,*; Montovani, Cristina d; Smith, Colette b; Johnson, Margaret c; Terenghi, Giorgio d; Youle, Mike c
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| Acetyl-L-carnitine - Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease | Acetyl-L-carnitine was administered Alzheimer's disease patients showed significantly less deterioration in their Mini-Mental Status and Alzheimer's Disease Assessment Scale test scores.
Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JN, McClure RJ.
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA 15213, USA. |
| | | | | Supplier: Tuck's Discount Vitamins USA Ltd. | | Brand: NOW Foods (USA) | | Case Size: N/A | | Acety L-Carnitine
100 caps | | | Stock #: 320021 | | Description: Acetyl-L-Carnitine is a naturally occurring high-energy, “improved” form of L-Carnitine. L-Carnitine is the train that fats ride when its time for them to go and be burned up for energy.
In addition to perking the ears of exercise and weight loss enthusiasts, this statement should catch the interest of individuals concerned about cardiovascular health. Two thirds of the heart’s energy comes from fats. It also plays a role in taking out the byproducts or toxins of the fatty acid oxidation process. In addition, Acetyl-L-Carnitine supports neurological health by enhancing the production of neurotransmitters involved in memory, as well as the production nerve growth factors in the brain.
L-Carnitine is produced in the body from the nutrients lysine, methionine, vitamin C, vitamin B3, vitamin B6, and iron. A deficiency is even one of these nutrients may compromise our own production of L-Carnitine, but fortunately, L-Carnitine is also found in food. Vegetarians need to take special care, however, because red meats are the richest sources of L-Carnitine, with little found in fruits and vegetables.
Beware of low quality Carnitine supplements containing the D-form of Carnitine. D-Carnitine is not only inferior, but may block the normal biochemical functioning of L-Carnitine and Acetyl-L-Carnitine. It is easier and cheaper for manufacturers to produce products that contain this impurity. Several years ago when this impurity was more common, reports surfaced from consumers about cardiovascular and muscular problems.
L-carnitine when combined with L-acetyl-carnitine, a related chemical, may improve sperm motility in men with fertility problems, according to new research by scientists at the University of Rome.
The researchers chose 60 infertile men between the ages of 20 and 40 to take a combination of L-carnitine and L-acetyl-carnitine or a placebo for six months. Two months after the patients had completed their course of supplements, the men who had taken L-carnitine and L-acetyl-carnitine had increased sperm concentration and movement.
NOW believes it has obtained the finest Acetyl-L-Carnitine and L-Carnitine available.
Some Quality Facts about NOW Acetyl-L-Carnitine:
Lonza of Switzerland supplied L-CARNIPURE®
Advanced manufacturing technique developed in 1991
Guaranteed 0.0% D-Carnitine.
Acetyl-L-Carnitine Hydrochloride
Crystalline White Powder
Assay 99.2% (typically 98.0 – 101.0%)
Heavy Metals less than 10 ppm
D-Carnitine Absent
Manufactured under Good Manufacturing Practices (cGMP)
Manufactured according to Kosher principles
Meets FCC, United States (USP) and European Pharmacopoeia (EP) standards | | Benefits & How it Works: L-Carnitine is a vitamin-like amino acid derivative. It plays an important role for maintaining energy production by transporting long-chain fatty acids into the mitochondrial matrix to be burned for energy. This function supports physical performance and weight management. Therefore, L-Carnitine and its esters, such as Acetyl-L-Carnitine and Propionyl-L-Carnitine, have received growing attentions for their uses in cardiovascular and neurological health.
L-Carnitine, along with its natural ester acylcarnitine, forms a critical part of the endogenous (natural to the body) carnitine pool in various tissues of mammals. The total L-Carnitine in human body is about 20 g, in which 98% is present in the skeletal and cardiac tissues, 1.4% in the liver and kidneys and 0.6% in extracellular fluids and other tissues. Of all these carnitine pools in the human body, about 25% are produced from the amino acids lysine and methionine and about 75% is derived directly from dietary sources such as meat, poultry, fish, and milk; with small amounts in wheat and avocados. So people with a limited diet of meat and dairy products tend to have lower L-Carnitine intakes.
L-Carnitine is a “conditionally essential” nutrient and a rare genetic disorder of L-carnitine metabolism causes carnitine deficiency, which is known to have major deleterious effects on the central nervous system. The limited intake of L-Carnitine can cause toxic accumulations of free fatty acids and the loss of energy. L-Carnitine is used worldwide as an effective treatment for carnitine deficiency and also has various nutritional and pharmaceutical applications. Several oral formulations, such as liquids, tablets and capsules, are available in the current market. NOW FOODS carries several L-Carnitine formulas and also carries Acetyl-L-Carnitine.
Since L-Carnitine powder is hygroscopic (water absorbing) and rapidly liquefies when it is exposed to air, NOW FOODS uses L-Carnitine-L-Tartrate, a stabilized form of L-Carnitine, in our formulas to offer our customers the full potency in stable products. Watch also for special moisture absorbing packets in some carnitine packages; keep these in the bottles until the product is all used.
L-Carnitine is has a sister form, D-Carnitine, which may be formed as an impurity when producing the natural “L form”. The “D form” may have considerable side effects or even toxic influences on biochemical processes because it may inhibit an enzyme called carnitine acetyl transferase, leading to a depletion of the body’s L-Carnitine reserves.
Separation and determination of any undesirable D-Carnitine is important to maintain the quality of our nutritional formulations and assure their proper function and safety. To maintain the quality of our products, NOW FOODS is developing an HPLC testing method for simultaneous separation of L-Carnitine, Acetyl-L-Carnitine and various impurities, which include D-forms and crotonoylbetain. The content of D-Carnitine allowed in the European Pharmacopoeia and United States Pharmacopoeia is limited to about 4%. Our HPLC method has high sensitivity and selectivity and allows the detection of an impurity in the D-form at less than 0.5%. By using this new method to test the potency and verify the purity of our L-Carnitine products, NOW FOODS ensures the best quality of L-Carnitine products for our customers, while avoiding potentially harmful impurities.
| | Dosages & Ingredients: Serving Size: 1 Capsule
Acetyl-L-Carnitine (from Acetyl-L-Carnitine HCl) (L-Carnipure®).........................500 mg
Suggested Usage: As a dietary supplement, take 1 capsule 1 to 3 times daily as needed.
Other Ingredients: Gelatin (capsule), Stearic Acid (vegetable source), Magnesium Stearate (vegetable source) and Cellulose.
Contains no: sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
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